En este libro Pedro Karczmarczyk se da a la tarea de recopilar ―además de colaborar con un texto propio― una serie de artículos que abordan las principales tradiciones de la filosofía contemporánea, en especial sobre un tema que se encuentra en el meollo del pensamiento filosófico: la cuestión del sujeto. Podemos pensar entonces que el título, El sujeto en cuestión, evoca de manera certera lo común que atraviesa la diversidad de enfoques; volviéndose el hilo de Ariadna que nos ayuda a (...) caminar por un laberinto poblado de gigantes filosóficos que, como es su célebre y problemática costumbre, hablan su propio idioma. Este cuestionamiento sobre la multívoca categoría de ‘sujeto’ (vocablo que ha sido entendido como sustrato-súbdito-sujeto de la consciencia entre otros) comienza con la necesaria ruptura respecto del espíritu filosófico moderno que creyó fervientemente en la posibilidad de delimitar ―y agotar― los modos y los medios a través de los cuales la consciencia (el sujeto) es capaz de representar el mundo. Cénit de este modo de pensar fue la filosofía de Kant, referente ineludible de muchos de los autores analizados en el presente libro que de un modo u otro se enfrentan a la pretensión fundacionista, ahistoricista y universalista de nuestro pasado filosófico. (shrink)

Dentro de la sociología francesa actual, Gilles Lipovetsky se ha convertido de forma paulatina en uno de los sociólogos con mayor proyección internacional, con sus finos análisis sobre las sociedades postmodernas. En este artículo se plantea una revisión crítica de las principales líneas argumentativas que expone el autor francés. El objetivo es el de reflexionar sobre las limitaciones de su aproximación a los conceptos de postmodernidad, hipermodernidad, y consumo.

El texto pretende señalar un recorrido cronológico por algunas de las obras más importantes de Theodor Adorno. Con ello se procura mostrar cómo en su filosofía, desde sus inicios hasta su última gran obra, hubo un desarrollo coherente en el cual el arte llegó a configurarse como un modelo crítico de la razón ilustrada, en tanto que él puede acoger y representar lo excluido, y por ello coartado, por la racionalidad instrumental.

For companies involved in the supply chain, proper warehousing management is crucial. Warehouse layout arrangement and operation play a critical role in a company’s ability to maintain and improve its competitiveness. Reducing costs and increasing efficiency are two of the most crucial warehousing goals. Deciding on the best warehouse layout is a remarkable optimization problem. This paper uses an optimization method to set bin allocations within an automated warehouse with particular characteristics. The warehouse’s initial layout and the automated platforms limit (...) the search and define the time required to move goods within the warehouse. With the help of historical data and the definition of the time needed to move goods, a mathematical model of warehouse operation was created. An optimization procedure based on the well-known Variable Neighbourhood Search algorithm is defined and applied to the problem. Experimental results demonstrate increments in the efficiency of warehousing operations. (shrink)

Los centros de educación superior son por definición espacios de generación de conocimiento, derivado de ello se vincula la aplicación de los valores primordiales que rigen el desarrollo académico y científico. Entre estos valores subyacen tales como honestidad, justicia, respeto, responsabilidad y confianza. Existen múltiples interpretaciones de integridad académica, este estudio se promueve el cual abarca todos los elementos mencionados como valores básicos del desarrollo social y universitario: honestidad, justicia, respeto, responsabilidad y confianza.Este estudio se orienta a conocer el grado (...) de transparencia, compromiso e integridad presente en las universidades en el desarrollo de su labor académica e investigadora. (shrink)

In recent years, the term populism has become indeed popular. Among its variants, a very particular one stands out. It is the so-called managerial populism, in which prominent businessmen have entered the arena of politics with a program focused on the regeneration of economic and social life. Donald Trump, perhaps, has been the most outstanding example. In this article, our aim is to analyze this phenomenon of managerial populism, addressing a number of issues. Firstly, we will discuss the emergence of (...) a certain type of charismatic leadership in business or management ideologies as a development that largely precedes the consolidation of these figures in the political scene; the implications of these ideologies in the political and social sphere; and the importance of the forms of discursive use of the concept of people in these popular discourses. (shrink)

The introduction of the notion of family resemblance represented a major shift in Wittgenstein’s thoughts on the meaning of words, moving away from a belief that words were well defined, to a view that words denoted less well defined categories of meaning. This paper presents the use of the notion of family resemblance in the area of machine learning as an example of the benefits that can accrue from adopting the kind of paradigm shift taken by Wittgenstein. The paper presents (...) a model capable of learning exemplars using the principle of family resemblance and adopting Bayesian networks for a representation of exemplars. An empirical evaluation is presented on three data sets and shows promising results that suggest that previous assumptions about the way we categories need reopening. (shrink)

Despite abundant evidence associating CD38 overexpression and CD4 T cell depletion in HIV infection, no causal relation has been investigated. To address this issue, a series of mechanisms are proposed, supported by evidence from different fields, by which CD38 overexpression can facilitate CD4 T cell depletion in HIV infection. According to this model, increased catalytic activity of CD38 may reduce CD4 T cells’ cytoplasmic nicotin‐amide adenine dinucleotide (NAD), leading to a chronic Warburg effect. This will reduce mitochondrial function. Simultaneously, CD38's (...) catalytic products ADPR and cADPR may be transported to the cytoplasm, where they can activate calcium channels and increase cytoplasmic Ca2+ concentrations, further altering mitochondrial integrity. These mechanisms will decrease the viability and regenerative capacity of CD4 T cells. These hypotheses can be tested experimentally, and might reveal novel therapeutic targets. (shrink)

El texto pretende señalar un recorrido cronológico por algunas de las obras más importantes de Theodor Adorno. Con ello se procura mostrar cómo en su filosofía, desde sus inicios hasta su última gran obra, hubo un desarrollo coherente en el cual el arte llegó a configurarse como un modelo crítico de la razón ilustrada, en tanto que él puede acoger y representar lo excluido, y por ello coartado, por la racionalidad instrumental.

Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together (...) researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals. (shrink)

Este artículo explora los recursos narrativos y visuales planteados en el cómic colombiano, desde 1992 hasta nuestros días, para describir representaciones distópicas de la ciudad de Bogotá. La distopía se entiende, en términos generales, como una visión negativa, para la humanidad, de un futuro posible o de un presente alterno, y se clasifica acá en distopías de fallo tecnológico, distopías de coerción simbólica/ coerción física, distopías de apocalipsis zombie/infectado y distopías de apocalipsis sobrenatural/no humano. Para la investigación se recopilaron las (...) publicaciones impresas disponibles desde 1992, de los cuales se seleccionaron aquellos que sucedieran o hicieran referencia a la ciudad de Bogotá. De los 45 cómics que cumplían dicho criterio, se identificaron y analizaron las 28 piezas que presentaron un escenario distópico. Entre los hallazgos fundamentales se encontró que la violencia y el conflicto, tanto simbólicos como físicos, son constantes en los diferentes escenarios distópicos identificados en la muestra, lo que refleja y proyecta la violencia histórica que vive un país como Colombia. (shrink)

Psychological flexibility is a key concept of acceptation and commitment therapy. This factor has been linked with psychological wellbeing and associated factors, such as quality of life, in cancer patients. These and other positive results of acceptation and commitment therapy in cancer patients found in previous research could be enhanced by using mhealth tools. A three-arm randomized superiority clinical trial, with a pre-post-follow-up repeated measures intergroup design with a 1:1:1 allocation ratio is proposed. A hundred and twenty cancer patients will (...) be randomly assigned to one of the following interventions: face-to-face ACT + mobile application, face-to-face ACT, and Waitlist control group. The primary expected outcome is to observe significant improvements in psychological flexibility acceptance and action questionnaire- II in the face-to-face ACT + app group, after comparing baseline and post-treatment scores, and the scores will remain stable in the two assessment points, 3 and 6 months after the intervention. Secondary expected outcomes are significant increasing scores in quality of life and post-traumatic-growth, and significant decreasing scores in anxiety and depression, insomnia and fatigue at the same assessment points. Also, it is expected that the scores of this group will be higher than the scores of the face-to-face ACT group and the waitlist control group. This study aims to assess the efficacy of a combined intervention for psychological flexibility and associated symptoms in cancer patients. The results of this protocol may help to consider the use of acceptation and commitment therapy and mhealth applications in cancer settings as a valid therapeutic choice.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT05126823]. (shrink)

Antibiotic use triggers evolutionary and ecological responses from bacteria, leading to antibiotic resistance and harmful patient outcomes. Two complementary strategies support long-term antibiotic effectiveness: conservation of existing therapies and production of novel antibiotics. Conservation encompasses infection control, antibiotic stewardship, and other public health interventions to prevent infection, which reduce antibiotic demand. Production of new antibiotics allows physicians to replace existing drugs rendered less effective by resistance.In recent years, physicians and policymakers have raised concerns about the pipeline for new antibiotics, pointing (...) to a decline in the number of antibiotics approved since the 1980s. This trend has been attributed to high research and development costs, low reimbursement for antibiotics, and regulatory standards for review and approval. Professional societies and researchers around the world have called for renewed emphasis on antimicrobial stewardship, while also supporting antibiotic research and development through grants, changes to intellectual property laws to extend market exclusivity periods, and modification of premarket testing regulations to reduce antibiotic development time and expenses. (shrink)

The goal of this essay is to expose the foundations of Enrique Dussel’s philosophy of liberation and to explain its contributions in the context of Latin-american thinking. In a postmetaphysical level of foundation, the philosophy of liberation adopts the ethos from semitic thinking and the Levinas’ hermeneutics of the «Other» with the proposal of formulate a criticism of eurocentrism and to build an alternative philosophical model. In front of the traditional paradigms of philosophy and philosophical historiography, Enrique Dussel (...) develops a new arquitectonics to report on the specificity of our thinking. (shrink)

El artículo es una crónica del "colloquium" celebrado en la "Academia Belgica" de Roma, del 15 al 17 de septiembre de 2011, acerca de los sermones agustinianos "ad populum" sobre el Nuevo Testamento. El artículo hace una presentación general de cada una de las contribuciones presentadas en el "colloquium", acentuando su aportación a los estudios agustinianos.

El artículo estudia la obra "De sancta uirginitate" desde un punto de vista eclesiológico, superando así la opinión según la cual sólo las mujeres consagradas a Dios son destinatarias de ella. Comenta también la polémica sobre la uirginitas a finales del siglo IV y principios del siglo V, y cómo presenta la virginidad el pensamiento agustiniano.

El presente artículo analiza sucintamente la redención como expresión de la soteriología agustiniana, formulada en cuanto descenso de Cristo hacia los hombres, tal y como este movimiento de abajamiento se retrata en diversas "Enarrationes in Psalmos", haciendo particular hincapié en las imágenes usadas por Agustín o en los misterios a los que él hace referencia, al hablar del descenso de Cristo para salvar a los hombres.

El artículo estudia el sintagma 'membrana et atramentum' en la obra agustiniana, para descubrir, a través de una lectura conjunta del corpus agustiniano, las diversas implicaciones que este sintagma conlleva en los aspectos semántico, semiótico y teológico.

En el presente artículo se presentan los espectáculos del anfiteatro tal y como aparecen en las obras de san Agustín, poniendo de manifiesto las diversas implicaciones y significados que para él tiene el anfiteatro, particularmente lo relativo a quienes llenan esos lugares y a la valoración que le merecen a san Agustín los espectáculos ahí desarrollados. Posteriormente se habla de la figura de los gladiadores, lo que representan para san Agustín, y de la utilización catequética en sus sermones.

En este trabajo se define formamente el concepto de representacion en química utilizando homomorfismos desde estructuras algebraicas, que llamamos sistemas de tipo C, en otras estructuras especiales de símbolos muy relacionados con los que son habituales en la qímica experimental. Para la definicion de los sistemas de tipo C se ha seleccionado un conjunto minimo de relaciones y funciones, que son necesarias para expresar proposiciones significativas en química. Tambien se define un lenguaje formal de primer orden adecuado a los sistemas (...) de tipo C, que llamamos L(C). EI resultado principal que se demuestra es que toda representación que verifica las mismas sentencias de L(C) que un sistema de tipo C, es necesariamente isomorfo a él. Se concluye por lo tanto que puede existir un problema linguístico subyacente en la aplicacion que de la mecaníca cuántica se hace en la química teórica.The concept of representation in chemistry bas been formallv defined by means of homomorphisms from algebraical structures, which we call type-C systems, to some special sets of symbols which can be related to the symbols ordinarily used in experimental chemistry. A minimum number of relations and functions, which would suffice to express significant propositions in chemistry, have been chosen to define type-C systems. A first order formal language L(C) adequate to type-C systems has been defined. It has been shown that each representation that verifies the same sentences of L(C) as a type-C system is necessarily isomorphic to it. It is concluded that a systematic study of the representation problem in chemistry is in order because a deep language problem underlies the application of quantum mechanies to chemical problems. (shrink)

There are many real-world applications like healthcare systems, job monitoring, well-being and personal fitness tracking, monitoring of elderly and frail people, assessment of rehabilitation and follow-up treatments, affording Fall Detection (FD) and ADL (Activity of Daily Living) identification, separately or even at a time. However, the two main drawbacks of these solutions are that most of the times, the devices deployed are obtrusive (devices worn on not quite common parts of the body like neck, waist and ankle) and the poor (...) battery life. Thus, this work proposes a low-power classification algorithm based on an Ensemble of KNN and K-Means algorithms (EKMeans) to identify Falls and High-Intensity ADL events such as running, jogging and climbing up stairs. The input of EKMeans are triaxial accelerometer data gathered from wrist-wearable devices. The proposal will be validated on the Fall&ADL publicly available datasets UMAFall, UCIFall and FallAllD, considering two kinds of activity labelling: Two-Class and Multi-Class. An exhaustive comparative study between our proposal, and the baseline algorithms KNN and a feed-forward Neural Network (NN) is deployed, where EKMeans outperformed clearly the Specificity (ADL classification) of the KNN and NN for the three datasets. Finally, a comparative battery consumption study has been included deploying the analyzed algorithms in a WearOS smartwatch, where EKMeans drains the battery from 100% to 0% in 27.45 hours, saving 5% and 21% concerning KNN and NN, respectively. Keywords: Human Activity Recognition, ADL Identification, Fall Detection TS Clustering, TS Classification, Wearable Devices, Low-Power HAR. (shrink)

Journal of Mathematical Logic, Volume 23, Issue 03, December 2023. The aim of this paper is to generalize and improve two of the main model-theoretic results of “Stable group theory and approximate subgroups” by Hrushovski to the context of piecewise hyperdefinable sets. The first one is the existence of Lie models. The second one is the Stabilizer Theorem. In the process, a systematic study of the structure of piecewise hyperdefinable sets is developed. In particular, we show the most significant properties (...) of their logic topologies. (shrink)

This article compares the De ordine and the De libero arbitrio in order to show how in the works after the so-called “Dialogues of Cassiciacum” a greater philosophical and dialectical complexity is evident. In particular, the complexity of the method used is analysed, the development of the topic of moral evil is highlighted, as well as the issue of the necessity of evil.

This paper investigates Augustine’s Letter 111 to expose the Bishop of Hippo’s stand on the problem of violent sexual abuse perpetrated on Catholic nuns and its consequence on their integrity. Having presented the general historical and sociopolitical context in which the letter was written, it surveys the question of violence in Augustine’s epistolary in general. The analysis of the final section of the Letter 111 shows that according to Augustine, despite the defloration of their virginity, raped holy women do not (...) lose their chastity so long as in their mind, they did not consent to lust. (shrink)

Augustine presents the unfolding of the nuptial mystery as a unitary tapestry on which the image of the Wedding of Christ-Church gradually emerges, and also its fulfillment in the Love of the man for the woman. The event of salvation is a nuptial mystery, the fruit of which is a new creation, through the participation in Christ’s Trinitarian communion. Every faithful can receive this gift which brings the mystery of the risen Christ back into life. This circularity of the Trinitarian, (...) Christological and anthropological layers of the mystery, find their point of convergence in the caritas. What Augustine synthesizes in an original way is this dynamic relationship, that is based in the circularity of the layers, through the role of the Spirit. The gift of charity founds unity in communion, being one and one body only in Christ. Thus, the Christians, thanks to Eucharistic and sacramental unity, become ‘members’ of the one Church-Bride, in which all form one Body. Marriage and virginity reveal themselves to be the two dimensions of the journey that human love takes, guided by the Spirit, to reach the fullness of divine love. Thus, in the ‘we’ of love, the divine ‘We’ is made present, and through “living in love” “the light of God” enters into the world. (shrink)

Augustine’s teaching on wealth and poverty, on the relations between the poor and the rich has been extensively studied in the past few decades. However, much attention has not been given to his considerations on the prosperity of the wicked and the tendency of the faithful to serve God for an immediate material reward. In this paper, I examine the bishop of Hippo’s preaching on this question. Predominantly, in his Sermones ad populum and Enarrationes in Psalmos, Augustine constantly calls his (...) flock to acknowledge the author of prosperity and of all good things as the Supreme Good, and to prefer him to all the ephemerous possessions they may have in this world. Above all, he encourages the faithful to despise the prosperity of the wicked which is only apparent and to hope for God himself their reward for serving him. (shrink)

En este trabajo se define formamente el concepto de representacion en química utilizando homomorfismos desde estructuras algebraicas, que llamamos sistemas de tipo C, en otras estructuras especiales de símbolos muy relacionados con los que son habituales en la qímica experimental. Para la definicion de los sistemas de tipo C se ha seleccionado un conjunto minimo de relaciones y funciones, que son necesarias para expresar proposiciones significativas en química. Tambien se define un lenguaje formal de primer orden adecuado a los sistemas (...) de tipo C, que llamamos L. EI resultado principal que se demuestra es que toda representación que verifica las mismas sentencias de L que un sistema de tipo C, es necesariamente isomorfo a él. Se concluye por lo tanto que puede existir un problema linguístico subyacente en la aplicacion que de la mecaníca cuántica se hace en la química teórica.The concept of representation in chemistry bas been formallv defined by means of homomorphisms from algebraical structures, which we call type-C systems, to some special sets of symbols which can be related to the symbols ordinarily used in experimental chemistry. A minimum number of relations and functions, which would suffice to express significant propositions in chemistry, have been chosen to define type-C systems. A first order formal language L adequate to type-C systems has been defined. It has been shown that each representation that verifies the same sentences of L as a type-C system is necessarily isomorphic to it. It is concluded that a systematic study of the representation problem in chemistry is in order because a deep language problem underlies the application of quantum mechanies to chemical problems. (shrink)

In the second book of Soliloquia, Augustine queries: what is ‘true’ and what is ‘false’. Through the examination, Augustine (Ratio) expresses the idea that ‘true’ is that which exists. Therefore, whatever exists is true; nothing will be false. But then, what is ‘false’? This paper will first clarify that the examination of ‘false’ in Soliloquia relates to Augustine’s awareness of the problem of sin. Already in Soliloquia, Augustine finds that the soul can have in itself the cause of sin so (...) as to be unable to have the truth. Secondly, the author examines how the epistemology of falsehood is developed in the early Augustine by examining his articles after Soliloquia, focusing on the concept of lying in De Genesi contra Manichaeos and De vera religione. This will show that Augustine's understanding of falsehood and lying is related to his soteriology. Thirdly, the paper focuses on q. 63 of De diversis quaestionibus LXXXIII, in order to clarify what Augustine thinks about the relationship between God and human soul, where Augustine notes the significance of knowing and confessing sin as the means of cooperative salvation already described in his early works. (shrink)

El artículo presenta, en primer lugar, una introducción al libro VIII del De Genesi ad litteram. Posteriormente pone de manifiesto sus principales temas exegéticos y teológicos. Se aborda en primera instancia, la recensión que hace san Agustín de los diversos comentarios anteriores a él sobre el tema del paraíso, así como su propia propuesta exegética. Se aborda asimismo la cuestión de la creación, el árbol del bien y del mal, la interpretación del trabajo del hombre en el jardín del Edén, (...) destacando la importancia y la dilogía del verbo latino colo (dar culto, cultivar). El artículo aborda asimismo la cuestión de la providencia divina, y se destacan los elementos trinitarios, cristológicos y antipelagianos que pueden encontrarse en el libro VIII del De Genesi ad litteram. Todos estos argumentos son abordados haciendo referencia a los comentarios agustinianos anteriores al libro del Génesis, particularmente el De Genesi aduersus manicheos y el De Genesi ad litteram imperfectus liber. (shrink)